1. Covent Garden — West End
The most central base: theatres, restaurants and the sights all within walking distance.
Covent Garden puts you in the middle of the West End, with the piazza, the Royal Opera House, dozens of theatres, and Trafalgar Square, the National Gallery and Soho a few minutes away on foot.
It is lively until late and hotels are pricey, but for a first visit nothing beats walking out of the door into the action.
Good to know: Rooms facing the piazza or main streets can be noisy at night; ask for a quiet side.